Ethanol hydrochloride → HCID 66885193, compound

HRID 1364264Notes

Reaction equation

HRID 1364264 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][N:20]4[C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[CH:23]=[CH:22][C:21]4=[O:30])[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.[Cl:31]CCCCN1C2C(=CC=CC=2)C=CC1=O.C(O)C.Cl>C(O)C>[ClH:31].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][N:20]4[C:29]5[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=5)[CH:23]=[CH:22][C:21]4=[O:30])[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 21887872Ethanol hydrochlorideHCID 24968722HCID 24968722, compoundHCID 64106163HCID 64106163, compound

Product 1

HCID 66885193HCID 66885193, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By a similar method as in Example 1, 1-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butyl]-1H-quinolin-2-one was prepared from 1-(4-chlorobutyl)-1H-quinolin-2-one, and after it was made into an ethanol solution, 1N hydrochloric acid ethanol solution was added thereto, precipitated crystals were separated by filtration, and thereby 1-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butyl]-1H-quinolin-2-one hydrochloride was obtained in the form of a white powder.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration

Sources & evidence

ORD record
ord-7caa0928650243868aee5ced743fdf09
Source dataset
uspto-grants-2011_02
Patent number
US07888362B2

Reaction notes

Loading…