HCID 11978937, compound → HCID 66886025, compound

HRID 1364274Notes

Reaction equation

HRID 1364274 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]4[CH:30]=[C:29]5[C:24]([CH2:25][CH2:26][N:27]([CH3:32])[C:28]5=[O:31])=[CH:23][CH:22]=4)[CH2:12][CH2:11]3)=[CH:7][CH:8]=[CH:9][C:2]1=2.[Cl:33]CCCCOC1C=C2C(CCN(C)C2=O)=CC=1.CO.Cl>CO>[ClH:33].[S:1]1[CH:5]=[CH:4][C:3]2[C:6]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][CH2:19][O:20][C:21]4[CH:30]=[C:29]5[C:24]([CH2:25][CH2:26][N:27]([CH3:32])[C:28]5=[O:31])=[CH:23][CH:22]=4)[CH2:14][CH2:15]3)=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 11978937HCID 11978937, compoundHCID 21893726Hydrochloride methanolHCID 66885306HCID 66885306, compound

Product 1

HCID 66886025HCID 66886025, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

By a similar method as in Example 1, 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one was prepared from 7-(4-chlorobutoxy)-2-methyl-3,4-dihydro-2H-isoquinolin-1-one, and after it was made into a methanol solution, 0.5N hydrochloric acid methanol solution was added thereto, precipitated crystals were separated by filtration, recrystallized from a mixed solvent of methanol-ethyl acetate and thereby 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-2-methyl-3,4-dihydro-2H-isoquinolin-1-one hydrochloride was obtained in the form of a white powder.

Workup

  1. additionwas added
  2. customprecipitated crystals
  3. customwere separated by filtration
  4. customrecrystallized from a mixed solvent of methanol-ethyl acetate

Sources & evidence

ORD record
ord-3858fd1e81d74ecdab7c1118600792d1
Source dataset
uspto-grants-2011_02
Patent number
US07888362B2

Reaction notes

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