HRID1364283

反应详情

EQUATION

反应方程式

REACTANTS

反应物

$结构：O=C(O)/C=C\C(=O)O$

HCID444266

Maleic acid

C4H4O4

结构：O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1

HCID11978813

Brexpiprazole

C25H27N3O2S

PRODUCTS

生成物

$结构：O=C(O)/C=C\C(=O)O.O=c1ccc2ccc(OCCCCN3CCN(c4cccc5sccc45)CC3)cc2[nH]1$

HCID66886299

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

2 次

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A methanol solution of maleic acid was added to a solution of 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one in methanol and dichloromethane and the solvent was evaporated under reduced pressure. The residue was recrystallized from 80% ethanol and thereby 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one maleate was obtained in the form of a white powder.

WORKUP

后处理

customthe solvent was evaporated under reduced pressure
customThe residue was recrystallized from 80% ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d28a499cf0514a9bbbef6e68d3291f30
来源数据集: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07888362B2
来源说明: uspto-grants-2011_02

反应 SMILES

[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[S:9]1[CH:13]=[CH:12][C:11]2[C:14]([N:18]3[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][CH2:27][O:28][C:29]4[CH:38]=[C:37]5[C:32]([CH:33]=[CH:34][C:35](=[O:39])[NH:36]5)=[CH:31][CH:30]=4)[CH2:20][CH2:19]3)=[CH:15][CH:16]=[CH:17][C:10]1=2>CO.ClCCl>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]\[C:4]([OH:6])=[O:5].[S:9]1[CH:13]=[CH:12][C:11]2[C:14]([N:18]3[CH2:19][CH2:20][N:21]([CH2:24][CH2:25][CH2:26][CH2:27][O:28][C:29]4[CH:38]=[C:37]5[C:32]([CH:33]=[CH:34][C:35](=[O:39])[NH:36]5)=[CH:31][CH:30]=4)[CH2:22][CH2:23]3)=[CH:15][CH:16]=[CH:17][C:10]1=2