Imidazole → HCID 178455454, compound

Participants

Reaction Steps

To a solution of trans-(4-hydroxymethyl-cyclohexyl)-methanol (50 g, 347 mmol) in DMF (700 mL) at rt was added sequentially imidazole (47.2 g, 693 mmol) and TBDMSCl (44.3 g, 294 mmol). The mixture was poured into water and the product extracted with ether. The combined organic extracts were dried over MgSO4 and concentrated under reduced pressure. Chromatography over SiO2 (Hex/EA 4:1, 2:1) gave the desired mono-protected compound as a colourless oil (40.1 g, 45% yield).

Provenance & Evidence