1,2-Dimethoxyethane → HCID 66921635, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 8-bromo-2-methoxy-[1,5]naphthyridine (1.2 g, 5 mmol), tetrakis(triphenylphosphine)palladium (0.29 g), K2CO3 (0.691 g) and 2,4,6-trivinyl-cyclotriboroxane pyridine complex (1.2 g, prepared according to J. Org. Chem. (2002), 67, 4969) in DME (40 mL) and water (12 mL) was heated at 85° C. under N2 overnight. The mixture was cooled to rt, diluted with water and extracted with ether. The combined org. extracts were dried over MgSO4 and concentrated in vacuo. The product (1 g of red oil) was used as such without further purification.

Provenance & Evidence