HCID 57670971, compound → HCID 57671112, compound

HRID 1364334Notes

Reaction equation

HRID 1364334 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[C:17](=[O:18])[CH:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27]OC)=[CH:22][CH:21]=3)[CH2:15][NH:14][C:13](=[O:30])[CH2:12]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[OH:31][C:32]1[CH:57]=[CH:56][C:55]([CH3:58])=[CH:54][C:33]=1/[CH:34]=[C:35]1/[C:36](=[O:53])[N:37]([S:43]([C:46]2[CH:51]=[CH:50][C:49]([Cl:52])=[CH:48][CH:47]=2)(=[O:45])=[O:44])[CH2:38][C:39](=[O:42])[NH:40][CH2:41]/1>>[CH3:23][O:26][CH2:27][O:31][C:32]1[CH:57]=[CH:56][C:55]([CH3:58])=[CH:54][C:33]=1/[CH:34]=[C:35]1/[C:36](=[O:53])[N:37]([S:43]([C:46]2[CH:47]=[CH:48][C:49]([Cl:52])=[CH:50][CH:51]=2)(=[O:44])=[O:45])[CH2:38][C:39](=[O:42])[NH:40][CH2:41]/1.[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]2[C:17](=[O:18])[CH:16]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=3)[CH2:15][NH:14][C:13](=[O:30])[CH2:12]2)(=[O:9])=[O:10])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 57670971HCID 57670971, compoundHCID 66934924HCID 66934924, compound

Product 2

HCID 57671112HCID 57671112, compoundHCID 66935148HCID 66935148, compound

Procedure

4-[(4-chlorophenyl)sulfonyl]-6-[4-(methoxymethoxy)benzyl]-1,4-diazepan-2,5-dione, synthesized by using, instead of the starting material of Reference Example 124, that is, the compound S120, the compound S121 for the similar procedure as in Reference Example 124, Example 1, and Example 29, was used instead of the starting material compound of Example 193 that is, (6E)-6-[2-(methoxymethoxy)-5-methylbenzylidene]-4-[(4-chlorophenyl)sulfonyl]-1,4-diazepan-2,5-dione, for the similar procedure as in Example 193 to obtain the title compound.

Sources & evidence

ORD record
ord-9a29119a2f6444f7a7fc1672dd195f3e
Source dataset
uspto-grants-2011_02
Patent number
US07888348B2

Reaction notes

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