Glycine tert-butyl ester hydrochloride → 3-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}benzoic acid

Participants

Role	Name	HCID	Charge
Reactant	Glycine tert-butyl ester hydrochloride	HCID 2725036	—
Reactant	tert-Butyl-3-aminobenzoate	HCID 2737408	—
Reactant	Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate	HCID 76588771	—
Product	3-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}benzoic acid	HCID 57671161	—

Reaction Steps

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, tert-butyl 3-aminobenzoate was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07888348B2
Source dataset	uspto-grants-2011_02
ORD ID	ord-e2860ac45c5a427aa864267be400a335
Source note	uspto-grants-2011_02