Glycine tert-butyl ester hydrochloride → HCID 57671028, compound

HRID 1364355Notes

Reaction equation

HRID 1364355 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22][CH2:23][C:24](OC(C)(C)C)=O)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.C(OC(=O)CN)(C)(C)C.C(OC(C1(N)C=[CH:58][C:57]([NH2:60])=[CH:56][CH2:55]1)=O)(C)(C)C>>[NH2:60][C:57]1[CH:58]=[CH:24][C:23]([NH:22][C:20]([C@H:19]([NH:18][C:16]([N:13]2[C:14](=[O:15])[CH:8]([CH2:7][C:6]3[CH:34]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=3[O:35][CH3:36])[CH2:9][NH:10][C:11](=[O:33])[CH2:12]2)=[O:17])[CH2:31][CH3:32])=[O:21])=[CH:55][CH:56]=1

Participants

4

Reactant 3

HCID 2725036Glycine tert-butyl ester hydrochlorideHCID 66935006HCID 66935006, compoundHCID 76588771Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate

Product 1

HCID 57671028HCID 57671028, compound

Procedure

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, 1-(tert-butoxycarbonyl)-1,4-phenylenediamine was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

Sources & evidence

ORD record
ord-e2bf68d2c4b14af9accd87a79d03dbe8
Source dataset
uspto-grants-2011_02
Patent number
US07888348B2

Reaction notes

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