4-Fluoro-3-nitrobenzoic acid → 3-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}-4-fluorobenzoic acid

HRID 1364360Notes

Reaction equation

HRID 1364360 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20](NC2C=C(C(O)=O)NC=2)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.[N+](C1C=C(C(O)=O)NC=1)([O-])=O.[F:48][C:49]1[CH:57]=[CH:56][C:52]([C:53]([OH:55])=[O:54])=[CH:51][C:50]=1[N+:58]([O-])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:58][C:50]2[CH:51]=[C:52]([CH:56]=[CH:57][C:49]=2[F:48])[C:53]([OH:55])=[O:54])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1

Participants

4

Reactant 3

HCID 679874-Fluoro-3-nitrobenzoic acidHCID 70165604-nitro-1H-pyrrole-2-carboxylic AcidHCID 576711444-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}-1h-pyrrole-2-carboxylic acid

Product 1

HCID 576710023-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}-4-fluorobenzoic acid

Procedure

Instead of the starting material compound of Example 262, that is, 4-nitropyrrole-2-carboxylic acid, 4-fluoro-3-nitrobenzoic acid was used for the similar procedure as in Example 262 to obtain the title compound.

Sources & evidence

ORD record
ord-ef0f9dd73e574dacaa23d315b8e2a4bf
Source dataset
uspto-grants-2011_02
Patent number
US07888348B2

Reaction notes

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