Dimethyl Sulfoxide → Tert-butyl 4-(1-but-2-enoxyethyl)-6-(2-methoxyphenyl)-2,2-dimethylquinoline-1-carboxylate

HRID 136445Notes

Reaction equation

HRID 136445 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[C:9]([CH3:29])([CH3:30])[CH:10]=[C:11]([CH:26]([CH3:27])[OH:28])[c:12]2[cH:13][c:14](-[c:18]3[c:19]([O:24][CH3:25])[cH:20][cH:21][cH:22][cH:23]3)[cH:15][cH:16][c:17]21.[CH2:41]([CH:42]=[CH:43][CH3:44])[Br:45].[CH3:31][Si:32]([N-:33][Si:34]([CH3:35])([CH3:36])[CH3:37])([CH3:38])[CH3:39].[CH3:47][S:48]([CH3:49])=[O:50].[Na+:40].[OH2:46]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[C:9]([CH3:29])([CH3:30])[CH:10]=[C:11]([CH:26]([CH3:27])[O:28][CH2:41][CH:42]=[CH:43][CH3:44])[c:12]2[cH:13][c:14](-[c:18]3[c:19]([O:24][CH3:25])[cH:20][cH:21][cH:22][cH:23]3)[cH:15][cH:16][c:17]21

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 923Sodium ionHCID 962WaterHCID 1224142-Butene, 1-bromo-HCID 3280088Npc316347HCID 207603324-(1-hydroxyethyl)-6-(2-methoxyphenyl)-2,2-dimethyl-2H-quinoline-1-carboxylic acid tert-butyl ester

Product 1

HCID 69152660Tert-butyl 4-(1-but-2-enoxyethyl)-6-(2-methoxyphenyl)-2,2-dimethylquinoline-1-carboxylate

Sources & evidence

ORD record
ord-aea744f580f147e69c0e5d08ecc0ce46
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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