Hydrochloric Acid → HCID 24777540, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (15° C.) and stirred solution of tin (II) chloride (0.4 g, 1.73 mmol) and conc. hydrochloric acid (1.2 mL) was added a solution of 2-(3-chlorophenoxymethyl)-6-nitrobenzonitrile (100.0 mg, 0.35 mmol). The reaction mixture was slowly warmed to room temperature and stirred for 3 hours. The reaction mixture was poured on to crushed-ice and potassium hydroxide solution, stirred, extracted with dichloromethane, filtered and dried. Purification by silica gel chromatography (dichloromethane) yielded 38 mg of 2-amino-6-(3-chlorophenoxymethyl)benzonitrile.

Provenance & Evidence