2-Amino-4,5-dimethyl-1,3-thiazole → HCID 87204943, compound

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Reaction Steps

The title compound was prepared in a manner analogous to the preparation of the title compound of Example 171, replacing 2-amino-1,3,4-thiadiazole with 4,5-dimethyl-2-aminothiazole. MS found: (M+H)+=425. 1H NMR (400 MHz, chloroform-D) δ ppm 1.20 (s, 3 H) 1.75-1.86 (m, J=8.65, 6.10 Hz, 1 H) 1.87-1.97 (m, 1 H) 1.91 (s, 3 H) 2.29 (s, 6 H) 2.50-2.57 (m, 2 H) 2.62 (d, J=16.28 Hz, 1 H) 2.80 (d, J=16.00 Hz, 1 H) 6.20 (s, 1 H) 7.19 (t, J=8.65 Hz, 2 H) 7.44 (dd, J=9.16, 4.58 Hz, 1 H) 7.51 (s, 1 H).

Provenance & Evidence