Cyclopentylamine → HCID 44419222, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of Example 181F (36.5 mg, 0.1 mmol) and cyclopentylamine (25.5 mg, 0.3 mmol) in N,N-dimethylacetamide (1.5 ml) was stirred in a sealed tube. This reaction mixture was heated in a microwave reactor at 160° C. for 20 min. and purified on HPLC (10 mM ammonium acetate, 5% acetonitirle in H2O/CH3CN) to give titled compound (33.5 mg, 81%). 1H NMR (300 MHz, DMSO-d6) δ 8.97 (t, J=6.0 Hz, 1H), 7.88 (d, J=9.0 Hz, 2H), 7.53 (d, J=9.0 Hz, 2H), 6.89 (s, 2H), and 6.70 (s, 1H), 6.27 (d, J=6.0 Hz, 2H), 4.57 (d, J=6.0 Hz, 2H), 4.57 (m, 1H), 3.18 (s, 3H), 1.95 (m, 1H), 1.67 (m, 2H), 1.50 (m, 4H); MS (APCI) m/z 414 [M+H]+, 412 [M−H]−.

Provenance & Evidence