Formic Acid → HCID 87205335, compound

Participants

Reaction Steps

To a suspension of Example 176 (73 mg, 0.2 mmol) in HCOOH (5 ml, 98%) was added AlNi3 (84 mg, 0.6 mmol). The mixture was refluxed for overnight and filtered after cooled down to r.t. The filtrate was concentrated and the remainder was purified on HPLC (10 mM ammonium acetate, 5% acetonitrile in H2O/CH3CN) to yield the titled compound (25 mg, 36%). 1H NMR (300 MHz, DMSO-d6) δ 10.23 (s, 1H), 9.20 (t, J=6.44 Hz, 1H) 8.46 (s, 1H), 7.95 (s, 1H), 7.88 (d, J=8.48 Hz, 1H), 7.55 (d, J=8.48 Hz, 2H), 7.08 (s, 1H) 4.57 (d, J=8.48 Hz, 2H), 4.54 (d, J=6.44 Hz, 2H), 3.18 (s, 3H), 1.35 (q, J=6.44 Hz, 3H); MS (APCI) m/z 378 [M+H]+, 376 [M−H]−.

Provenance & Evidence