反应详情

温度

0 °C

To a suspension of (4-methanesulfonyl-2-trifluoromethyl-phenyl)-methanol (50.3 g, 0.20 mol) in dry Et2O (400 ml), cooled to 0° C., is added PBr3 (6.5 ml, 0.07 mol) dropwise over 10 min. A sticky, thick yellow suspension forms which upon agitation and warming to room temperature changes to a fine white suspension. The reaction mixture is cooled again to 0° C. and water (200 ml) is added slowly. The suspension is neutralised at 10° C. with 4N NaOH aq (30 ml). The product is collected by filtration to give a white solid which is dried at 50° C. under high vacuum.

1. temperatureA sticky, thick yellow suspension forms which upon agitation and warming to room temperature changes to a fine white suspension
2. temperatureThe reaction mixture is cooled again to 0° C.
3. filtrationThe product is collected by filtration
4. customto give a white solid which
5. customis dried at 50° C. under high vacuum