4-Chloro-3-(pyridin-2-yl)aniline → HCID 66966830, compound

HRID 1364614Notes

Reaction equation

[C:1]([CH:8]([NH2:19])[C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=O)=[C:11]([Cl:18])[CH:10]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[Cl:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[CH:23][C:22]=1[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=1>>[Cl:18][C:11]1[CH:10]=[C:9]([CH:8]([C:1]([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2])[NH2:19])[CH:17]=[CH:16][C:12]=1[C:13]([NH:25][C:24]1[CH:26]=[CH:27][C:21]([Cl:20])=[C:22]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=2)[CH:23]=1)=[O:15]

Participants

Reactant 2

HCID 401519254-Chloro-3-(pyridin-2-yl)aniline

HCID 66878084HCID 66878084, compound

Product 1

HCID 66966830HCID 66966830, compound

Procedure

General procedure G was used to couple 4-(BOC-aminomethyl)-2-chloro-benzoic acid and 4-chloro-3-(pyridin-2-yl)aniline to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(BOC-aminomethyl)-benzamide with. The crude reaction mixture was treated to TFA and trace water for 1 h prior to concentrating to dryness to yield 2-chloro-N-(4-chloro-3-(pyridin-2-yl)-phenyl)-4-(aminomethyl)-benzamide.

Sources & evidence

ORD record: ord-e084775f66d642fdbbdaeda1aad734dc
Source dataset: uspto-grants-2011_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07888364B2

Reaction notes

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