5-Methanesulfonylthiophene-2-carboxylic acid → HCID 58614768, compound

HRID 1364637Notes

Reaction equation

HRID 1364637 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1.[CH3:15][S:16]([C:19]1[S:23][C:22]([C:24](O)=[O:25])=[CH:21][CH:20]=1)(=[O:18])=[O:17]>>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:24]([C:22]2[S:23][C:19]([S:16]([CH3:15])(=[O:18])=[O:17])=[CH:20][CH:21]=2)=[O:25])=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1

Participants

3

Reactant 2

HCID 27404975-Methanesulfonylthiophene-2-carboxylic acidHCID 401519254-Chloro-3-(pyridin-2-yl)aniline

Product 1

HCID 58614768HCID 58614768, compound

Procedure

Procedure G was used to couple 4-chloro-3-(pyridin-2-yl)aniline (40 mg) and 5-(methylsulfonyl)thiophene-2-carboxylic acid to produce N-(4-chloro-3-(pyridin-2-yl)phenyl)-5-(methylsulfonyl)thiophene-2-carboxamide. MS (Q1) 393.0 (M)+.

Sources & evidence

ORD record
ord-4067d0802fe6468e9731f377ed07aa13
Source dataset
uspto-grants-2011_02
Patent number
US07888364B2

Reaction notes

Loading…