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HRID1364661

反应详情

EQUATION

反应方程式

HRID 1364661 的结构方程式

REACTANTS

反应物

2
结构：Fc1ccc(Br)nc1
HCID2783171

2-Bromo-5-fluoropyridine

C5H3BrFN

结构：Cc1nc(C(F)(F)F)ccc1C(=O)Nc1ccc(Cl)c(B2OC(C)(C)C(C)(C)O2)c1
HCID66896658

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nc(C(F)(F)F)ccc1C(=O)Nc1ccc(Cl)c(-c2ccc(F)cn2)c1
HCID58614924

未命名化合物

PROCEDURE

实验过程

N-(4-chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide (˜1 mmol) was used in Procedure A with 5-fluoro-2-bromopyridine (1 mmol). Purified by silica gel chromatography (5-45% ethyl acetate/hexanes) to yield N-(4-chloro-3-(5-fluoropyridin-2-yl)phenyl)-2-methyl-6-(trifluoromethyl)nicotinamide as a tan solid: MS (Q1) 409 (M)+.

WORKUP

后处理

  1. customPurified by silica gel chromatography (5-45% ethyl acetate/hexanes)