HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → Methyl 4-(bromomethyl)-2-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Methyl 4-(hydroxymethyl)-2-methylbenzoate | HCID 23021531 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 4-(bromomethyl)-2-methylbenzoate | HCID 19372658 | — |
Reaction Steps
220 mg of methyl 4-(hydroxymethyl)-2-methylbenzoate was cooled to 0° C. in 5 mL of DCM before adding 260 mg of Triphenylphosphine and 395 mg of NBS. The reaction was concentrated and directly purified via ISCO Combi-Flash to give pure methyl 4-(bromomethyl)-2-methylbenzoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07888364B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-75d4a7b1a9b84941ad6ca9d0bf53b990 |
| Source note | uspto-grants-2011_02 |