HCID 66877087, compound → HCID 178512133, compound

HRID 1364952Notes

Reaction equation

HRID 1364952 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[CH:21]=[CH:20][C:14]([C:15](=[NH:19])OCC)=[CH:13][CH:12]=2)=[O:10])=[CH:4][C:3]=1[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=1.[NH:28]1[CH:32]=[C:31]([CH2:33][CH2:34][NH2:35])[N:30]=[CH:29]1>CO>[NH:28]1[CH:32]=[C:31]([CH2:33][CH2:34][NH:35][C:15]([C:14]2[CH:20]=[CH:21][C:11]([C:9]([NH:8][C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=4)[CH:4]=3)=[O:10])=[CH:12][CH:13]=2)=[NH:19])[N:30]=[CH:29]1

Participants

4

Reactant 2

HCID 66877087HCID 66877087, compoundHCID 178419017HCID 178419017, compound

Product 1

HCID 178512133HCID 178512133, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Ethyl 4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)benzimidate (2.0 ml of a 0.075 M methanol solution, 0.15 mmol) was treated with 2-(1H-imidazol-4-yl)ethanamine (25 mg, 0.23 mmol) via procedure W to afford 90 mg of 4-(N-(2-(1H-imidazol-4-yl)ethyl)carbamimidoyl)-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzamide. MS (Q1) 445 (M)+.

Sources & evidence

ORD record
ord-c95a37f962954bbda64536ac0a090f17
Source dataset
uspto-grants-2011_02
Patent number
US07888364B2

Reaction notes

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