HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 21105285, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Reactant | 2-bromo-1H-indole | HCID 11805631 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21105285 | HCID 21105285 | — |
Reaction Steps
The 2-bromoindole from example 2 was N-alkylated with tert-butylbromoacetate using NaH in DMF and the tert-butyl ester cleaved with TFA as described in example 6 to give the title compound of example 8 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07888363B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-129b403c4b2f49e4860492c46fd10ae8 |
| Source note | uspto-grants-2011_02 |