Sodium Hydroxide → HCID 11625348, compound

Participants

Reaction Conditions

Reaction Steps

5 mL 10% sodium hydroxide were added to a suspension of 2-[4-(2-oxo-4H-benzo[d][1,3]oxazin-1-yl)-piperidine-1-yl]-N-(1-oxo-indan-5-yl)-acetamide (25 mg, 0.06 mmols) in 5 mL ethanol. The resulting mixture was heated to 50° C. for 2 hours, cooled, the ethanol was evaporated and the aqueous phase was neutralized and extracted with methylene chloride (2×15 mL). The combined organic extracts were washed with water, dried over sodium sulfate and evaporated to dryness. The crude material was purified via a silica gel column, eluting with ethyl acetate. 15 mg of a white solid were obtained, i.e. a yield of 64%.

Provenance & Evidence