4-Cyanobenzoic acid → HCID 67111403, compound

Participants

Reaction Steps

Under an argon atmosphere, a mixture of 4-cyanobenzoic acid (7.2 mmol), L-tert-leucinol (6.0 mmol), Zn4(OCOCF3)6O (0.3 mmol) and chlorobenzene (10 mL) was heated under reflux for 18 hours. From the resulting solution, the solvent was removed using an evaporator, and the residues were purified by silica gel column chromatography (hexane/ethyl acetate=10/1 (V/V)) to give (S)-4-tert-butyl-2-(4-cyanophenyl)-1,3-oxazoline in 78% yield.

Provenance & Evidence