Methyl 4-(hydroxymethyl)benzoate → HCID 67111423, compound

Participants

Reaction Steps

Under an argon atmosphere, a mixture of methyl 4-hydroxymethylbenzoate (1.5 mmol), (L)-valinol (1.8 mmol), Zn4(OCOCF3)6O (0.15 mmol) and chlorobenzene (2.5 mL) was heated under reflux for 12 hours. From the resulting solution, the solvent was removed using an evaporator, and the residues were purified by silica gel column chromatography to give (S)-4-isopropyl-2-(4-hydroxymethylphenyl)-1,3-oxazoline in 66% yield. The compound was identified by comparison with physical property data of the known compound.

Provenance & Evidence