2-Aminopyrimidine-5-boronic acid, pinacol ester → HCID 58233942, compound

Participants

Reaction Steps

4-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperazine-1-sulfonic acid dimethylamide (Example 28) was reacted with 2-aminopyrimidine-5-boronic acid pinacol ester in General Procedure A. Purification on silica yielded 112. NMR (CDCl3): 2.51-2.55 (4H, m CH2), 2.75 (6H, s, Me), 3.22-3.25 (4H, m, CH2), 3.77 (2H, s, CH2), 3.78-3.82 (4H, m, CH2), 3.94-3.97 (4H, m, CH2), 5.14 (2H, br s, NH2), 7.20 (1H, s, Ar) and 9.20 (2H, s, Ar). MS: (ESI+): MH+=520.34.

Provenance & Evidence