4-Methanesulfonylpiperidine hydrochloride → 2-Chloro-6-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 1365171Notes

Reaction equation

HRID 1365171 reaction equation
Cl.[CH3:2][S:3]([CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)(=[O:5])=[O:4].[Cl:12][C:13]1[N:14]=[C:15]([N:24]2[CH2:29][CH2:28][O:27][CH2:26][CH2:25]2)[C:16]2[S:21][C:20]([CH:22]=O)=[CH:19][C:17]=2[N:18]=1>>[Cl:12][C:13]1[N:14]=[C:15]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[C:16]2[S:21][C:20]([CH2:22][N:9]3[CH2:10][CH2:11][CH:6]([S:3]([CH3:2])(=[O:5])=[O:4])[CH2:7][CH2:8]3)=[CH:19][C:17]=2[N:18]=1

Participants

3

Reactant 2

HCID 230616984-Methanesulfonylpiperidine hydrochlorideHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 574940442-Chloro-6-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Procedure

4-Methanesulfonyl-piperidine hydrochloride salt was reacted with 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde 10 following General Procedure B-3. Purification on silica yielded 2-chloro-6-(4-methanesulfonyl-piperidin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine.

Workup

  1. customPurification on silica

Sources & evidence

ORD record
ord-a061786eb6e64cdbaa6c5c3dc494162a
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

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