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HRID1365244

反应详情

EQUATION

反应方程式

HRID 1365244 的结构方程式

REACTANTS

反应物

2
结构：OB(O)c1cccnc1
HCID2734378

3-Pyridinylboronic acid

C5H6BNO2

结构：C[C@H](O)C(=O)N1CCN(Cc2cc3nc(Cl)nc(N4CCOCC4)c3s2)CC1
HCID86623527

(S)-1-(4-((2-chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one

C18H24ClN5O3S

PRODUCTS

生成物

1
结构：C[C@H](O)C(=O)N1CCN(Cc2cc3nc(-c4cccnc4)nc(N4CCOCC4)c3s2)CC1
HCID58234024

未命名化合物

收率 27%

PROCEDURE

实验过程

(S)-1-(4-((2-Chloro-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one (61 mg) was reacted with 28 mg of pyridin-3-yl-3-boronic acid via General Procedure A to give 18.1 mg of 212. MS (Q1) 469.3 (M)+.