Triethylamine → HCID 46180234, compound

Participants

Reaction Steps

To N-Boc-piperazine (500 mg) in DCM (10 ml) was added triethylamine (450 μl) and 3-fluorobenzenesulfonyl chloride (390 μl). The reaction mixture was stirred at room temperature overnight, then partitioned between dichloromethane and water, washed with brine, organics were dried over MgSO4, filtered and volatiles removed in vacuo to give 4-(3-fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (919 mg).

Provenance & Evidence