4-Phenylpiperidin-4-ol → HCID 86623539, compound

HRID 1365313Notes

Reaction equation

HRID 1365313 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[OH:19][C:20]1([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:23]3[CH2:22][CH2:21][C:20]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)([OH:19])[CH2:25][CH2:24]3)=[CH:8][C:6]=2[N:7]=1

Participants

3

Reactant 2

HCID 963874-Phenylpiperidin-4-olHCID 457899852-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

Product 1

HCID 86623539HCID 86623539, compound

Procedure

Reaction between 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde 10 (Example 3) and 4-hydroxy-4-phenylpiperidine via General Procedure B-3 yielded 1-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-4-phenyl-piperidin-4-ol.

Sources & evidence

ORD record
ord-885dd7dbdcd04a1bb964ea6df95f7999
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

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