HCID 17750474, compound → 6-(4-Morpholino-6-((4-n-methylsulfonylpiperazin-1-yl)methyl)thieno[2,3-d]pyrimidin-2-yl)pyridin-2-amine

HRID 1365326Notes

Reaction equation

HRID 1365326 reaction equation
Cl[C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[CH:10]=[C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]([S:18]([CH3:21])(=[O:20])=[O:19])[CH2:14][CH2:13]3)[S:8][C:6]=2[N:7]=1.[NH2:28][C:29]1[N:34]=[C:33](B2OC(C)(C)C(C)(C)O2)[CH:32]=[CH:31][CH:30]=1>>[O:25]1[CH2:26][CH2:27][N:22]([C:4]2[C:5]3[CH:10]=[C:9]([CH2:11][N:12]4[CH2:17][CH2:16][N:15]([S:18]([CH3:21])(=[O:20])=[O:19])[CH2:14][CH2:13]4)[S:8][C:6]=3[N:7]=[C:2]([C:33]3[N:34]=[C:29]([NH2:28])[CH:30]=[CH:31][CH:32]=3)[N:3]=2)[CH2:23][CH2:24]1

Participants

3

Reactant 2

HCID 17750474HCID 17750474, compoundHCID 568339462-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[2,3-d]pyrimidine

Product 1

HCID 582339936-(4-Morpholino-6-((4-n-methylsulfonylpiperazin-1-yl)methyl)thieno[2,3-d]pyrimidin-2-yl)pyridin-2-amine

Procedure

2-Chloro-4-morpholino-6-((4-N-methylsulfonylpiperazin-1-yl)methyl)thieno[2,3-d]pyrimidine (0.44 mM) and 6-aminopyridine-2-boronic acid pinacol ester were coupled using General Procedure A to give 297 (TFA salt) after reverse-phase HPLC purification. MS (Q1) 491 (M+)

Sources & evidence

ORD record
ord-5e0c274c27894a40ba97a104aa7dc24a
Source dataset
uspto-grants-2011_02
Patent number
US07888352B2

Reaction notes

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