2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-(4-Morpholino-6-(1-(4-n-methylsulfonylpiperazin-1-yl)ethyl)thieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

Participants

Reaction Steps

2-Chloro-6-[1-(4-methanesulfonyl-piperazin-1-yl)-ethyl]-4-morpholin-4-yl-thieno[3,2-d]pyrimidine was reacted with 2-aminopyrimidine-5-boronic acid pinacol ester in General Procedure A. Purification on silica yielded 300. NMR: (CDCl3): 1.44 (3H, d, J 7.1, Me), 2.52-2.64 (4H, m, CH2), 2.73 (3H, s, Me), 3.21-3.23 (4H, m, CH2), 3.80-3.83 (4H, m, CH2), 3.94-4.06 (5H, m), 5.16 (2H, s, NH2) and 9.20 (2H, s, Ar). MS: (ESI+): MH+=505.20

Provenance & Evidence