HRID1365411

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：OC1CCN(Cc2cc3c(N4CCOCC4)nc(Cl)nc3s2)C1

HCID58233924

未命名化合物

结构：CN(C(=O)OC(C)(C)C)c1ncc(B2OC(C)(C)C(C)(C)O2)cn1

HCID58234002

未命名化合物

PRODUCTS

生成物

结构：CNc1ncc(-c2nc(N3CCOCC3)c3cc(CN4CCC(O)C4)sc3n2)cn1

HCID58233948

未命名化合物

收率 29%

PROCEDURE

实验过程

1-((2-chloro-4-morpholinothieno[2,3-d]pyrimidin-6-yl)methyl)pyrrolidin-3-ol (235 mg, 0.67 mmol) was utilized in a Suzuki coupling with tert-butyl methyl(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-yl)carbamate (311 mg, 0.93 mmol) according to General Procedure Suzuki to provide 380 (83 mg) after reverse phase HPLC purification. MS (Q1) 428 (M)+