HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1365463Generated: October 30, 2026
Phosphorus tribromide → 4-(6-(Bromomethyl)-2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)morpholine
https://huagongshe.com/reaction/1365463
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | (2-Chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methanol | HCID 78358255 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-(6-(Bromomethyl)-2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)morpholine | HCID 78358256 | — |
Reaction Steps
To a stirring suspension (2-chloro-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl)-methanol in toluene at 40° C. was added PBr3 and the reaction mixture stirred at 100° C. overnight. DCM/saturated aqueous NaHCO3 extraction of the cooled mixture gave 6-bromomethyl-2-chloro-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07888352B2 |
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| Source dataset | uspto-grants-2011_02 |
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| ORD ID | ord-af09412dc74244faa6bb095d70b0dd36 |
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| Source note | uspto-grants-2011_02 |
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