反应详情

(S)-methyl 3-(5-chloropyridin-2-yl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)-3-((R)-2-methylpropan-2-ylsulfinamido)propanoate (0.075 g, 0.16 mmol) was dissolved in MeOH (2 mL). At RT, 4.0M HCl in dioxane (2 mL) was added and the reaction mixture stirred for 30 min. The reaction mixture was diluted with EtOAc (50 mL), transferred to a separation funnel and washed with 1.0M NaOH (ca.20 mL). The organic portion was dried over anhydrous Na2SO4, decanted and concentrated yielding (S)-methyl 3-amino-3-(5-chloropyridin-2-yl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)propanoate as a colorless oil, (0.062 g, crude quantitative yield). LCMS: 1.37 min [M+1] 377.1 (2 min gradient, MeOH/H2O 0.1% TFA).

1. customtransferred to a separation funnel
2. washwashed with 1.0M NaOH (ca.20 mL)
3. dry with materialThe organic portion was dried over anhydrous Na2SO4
4. customdecanted
5. concentrationconcentrated