Urea → HCID 86613588, compound

Participants

Reaction Steps

(S)-3-amino-3-(5-chloropyridin-2-yl)-3-(3-fluoro-5-(trifluoromethyl)phenyl) propanamide (0.031 g, 0.085 mmol) was converted to the urea as described in Procedure 2. (S)-1-(3-amino-1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-3-oxopropyl)-3-(3-fluorophenyl)urea (0.023 g, 56% yield) was isolated after purification by reverse phase prep HPLC: YMC ODSA 30×100 mm, 20-100% MeOH/H2O (0.1% TFA) gradient over 10 min, flow rate 20 mL/min eluting at a retention time of 10.3 min. LCMS: 1.98 min [M+1] 499.1 (2 min gradient, MeOH/H2O 0.1% TFA).

Provenance & Evidence