Chlorotrimethylsilane → HCID 58921454, compound

Temperature

-37.5 °C

To an oven-dried round bottomed flask was added nBuLi (2.5 M in hexanes, 3.6 mL, 9.0 mmol, 1.1 eq) at −45 to −40° C. under N2. An Et2O solution (12 mL) of 2-bromo-6-methoxypyridine (1 mL, 8.14 mmol) was added dropwise at the above temperature. The resulting light brownish yellow solution was stirred at −40 to −35° C. for 20 min. The mixture was cooled to −78° C., an Et2O solution (3 ml) of 3-fluoro-5-trifluoromethyl-benzonitrile (1.50 g, 7.94 mmol) was added dropwise at −78 to −70° C. The resulting solution was stirred at this temperature for 1 h. Pretreated TMSCl (1.08 mL, 8.55 mmol, 1.05 eq) was added dropwise at −78° C. The mixture was allowed to warm to room temperature for 30 min, and then stirred at room temperature for 30 min. The reaction mixture was cooled back to −78° C., and benzyl magnesium chloride (4.1 ml, 8.2 mmol) was added dropwise. The resulting mixture was stirred at −78° C. for 0.8 h, and then warmed up to room temperature for 1 h. The reaction mixture was quenched by adding sat'd NH4Cl and 1N HCl, and stirred for 10 min. The resulting solution was extracted with EtOAc, washed with 1N NaOH, saturated NaHCO3, H2O, brine, dried over MgSO4, filtered, and concentrated to dryness. The residue was purified by flash chromatography (silica gel, hexanes/EtOAc) to give 1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(6-methoxypyridin-2-yl)-2-phenylethanamine as light brownish gum (1.42 g, yield: 44.7%). LC-MS ESI (10-90% MeOH in H2O with 0.1% TFA in a 4-min run), retention time=3.20 min, 391.12 (M+H); 1H NMR (400 MHz, CDCl3) δ ppm 7.73 (s, 1 H), 7.47-7.57 (m, 2 H), 7.11-7.21 (m, 4 H), 6.99 (d, J=7.6 Hz, 1 H), 6.80 (dd, J=7.6, 2.0 Hz, 2 H), 6.61 (d, J=8.1 Hz, 1 H), 3.93 (s, 3H), 3.92 (d, J=13 Hz, 1 H) 3.40 (d, J=13 Hz, 1 H).

1. temperatureThe mixture was cooled to −78° C.
2. stirringThe resulting solution was stirred at this temperature for 1 h
3. temperatureto warm to room temperature for 30 min
4. stirringstirred at room temperature for 30 min
5. temperatureThe reaction mixture was cooled back to −78° C.
6. stirringThe resulting mixture was stirred at −78° C. for 0.8 h
7. temperaturewarmed up to room temperature for 1 h
8. customThe reaction mixture was quenched
9. additionby adding sat'd NH4Cl and 1N HCl
10. stirringstirred for 10 min
11. extractionThe resulting solution was extracted with EtOAc
12. washwashed with 1N NaOH, saturated NaHCO3, H2O, brine
13. dry with materialdried over MgSO4
14. filtrationfiltered
15. concentrationconcentrated to dryness
16. customThe residue was purified by flash chromatography (silica gel, hexanes/EtOAc)

ORD record

ord-8d48367a31934fff8ff68540c0832226

Source dataset

uspto-grants-2011_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07888376B2