Trifluoroacetic acid → HCID 58920021, compound

Participants

Reaction Steps

To a solution of (S)-tert-butyl-2-(3-(1-(5-chloropyridin-2-yl)-1-(4-fluoro-3-(trifluoromethyl)benzamido)-2-phenylethyl)-5-fluorophenoxy)acetate (27 mg, 0.04 mmol) in CH2Cl2 (1 mL) was added TFA (95 mg, 0.836 mmol). The mixture was stirred at room temperature for 2 h, and the solvent was removed to give (S)-2-(3-(1-(5-chloropyridin-2-yl)-1-(4-fluoro-3-(trifluoromethyl)benzamido)-2-phenylethyl)-5-fluorophenoxy)acetic acid as an white foam (25 mg, 100% yield). LCMS: RT=4.08 min [M+H] 591.46 (LCMS Method 1); 1H NMR (400 MHz, CDCl3) δ 3.69 (d, J=12.74 Hz, 1 H), 4.40 (d, J=13.18 Hz, 1 H), 6.53 (d, J=7.47 Hz, 3 H), 6.76 (d, J=9.23 Hz, 1 H), 6.91 (s, 1 H), 7.05 (t, J=7.47 Hz, 2 H), 7.15 (t, J=7.47 Hz, 7.25 −7.34 (m, 2 H), 7.78 (dd, J=8.57, 2.42 Hz, 1 H), 7.86 (ddd, J=8.68, 2.31, 2.20 Hz, 1 H), 7.91-7.98 (m, 1 H), 8.36 (d, J=2.20 Hz, 1 H), 9.30 (s, 1 H).

Provenance & Evidence