Potassium Carbonate → HCID 58920290, compound

Participants

Reaction Steps

To a solution of 1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(5-methoxy pyridin-2-yl)-2-phenylethanamine (200 mg, 0.512 mmol) in THF (2 mL) was added 2N K2CO3 (0.5 mL, 1.0 mmol) and isopropenyl chloroformate (100 μl, 1.02 mmol). The resulting mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure and the residue was dried in vacuo to yield prop-1-en-2-yl 1-(3-fluoro-5-(trifluoromethyl)phenyl)-1-(5-methoxypyridin-2-yl)-2-phenylethylcarbamate as white powder (120 mg, 50%). LCMS: RT=3.56 min [M+H] 475.2 (LCMS Method 1).

Provenance & Evidence