Trifluoroacetic acid → HCID 58920017, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-(3-(dibenzylamino)-2,2-difluoropropoxy)butanoate (120 mg, 0.29 mmol) in EtOH (1 mL) was added 50 mg Pd(OH)2 (10 mg, 20% on C) followed by the addition of TFA (25 μL). The reaction mixture was stirred at room temperature under H2 for 18 h. The solid was removed by filtration and the filtrate was concentrated under reduced pressure to yield tert-butyl 4-(3-amino-2,2-difluoropropoxy)butanoate (50 mg, 72% yield).

Provenance & Evidence