HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2,6-Dichlorobenzamido)pent-4-enoic acid methyl ester → (E)-2-(2,6-dichlorobenzamido)-5-[4-(4-methoxyoxepan-4-yl)phenyl]pent-4-enoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2,6-Dichlorobenzamido)pent-4-enoic acid methyl ester | HCID 57762518 | — |
| Reactant | 4-(4-Iodophenyl)-4-methoxyoxepane | HCID 57762612 | — |
| Product | (E)-2-(2,6-dichlorobenzamido)-5-[4-(4-methoxyoxepan-4-yl)phenyl]pent-4-enoic acid methyl ester | HCID 57762643 | 85.6% |
Reaction Steps
In the same manner as in Example 1, 2-(2,6-dichlorobenzamido)pent-4-enoic acid methyl ester (46 mg) was reacted with 4-(4-iodophenyl)-4-methoxyoxepane (60 mg) to obtain (E)-2-(2,6-dichlorobenzamido)-5-[4-(4-methoxyoxepan-4-yl)phenyl]pent-4-enoic acid methyl ester (66 mg). Column chromatography (silica gel, eluent: hexane/ethyl acetate=2/1) was used for purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893046B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-06c397cccf2a4e1b99889f0c792a9712 |
| Source note | uspto-grants-2011_02 |