Toluene → 6-[2-chloro-4-(5-methylthiazol-2-yl)phenyl]-8-ethyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([Cl:35])[c:5](-[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]([NH:16][c:17]4[cH:18][cH:19][c:20]([N:23]5[CH2:24][CH2:25][N:26]([CH3:29])[CH2:27][CH2:28]5)[cH:21][cH:22]4)[n:14][cH:15]3)[n:30]([CH2:33][CH3:34])[c:31]2=[O:32])[cH:6][cH:7]1.[CH3:132][c:133]1[cH:134][cH:135][cH:136][cH:137][cH:138]1.[CH3:36][c:37]1[cH:38][n:39][c:40]([Sn:42]([CH2:43][CH2:44][CH2:45][CH3:46])([CH2:47][CH2:48][CH2:49][CH3:50])[CH2:51][CH2:52][CH2:53][CH3:54])[s:41]1.[cH:55]1[cH:56][cH:57][c:58]([P:59]([Pd:60]([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)([c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[c:74]2[cH:75][cH:76][cH:77][cH:78][cH:79]2)([P:80]([c:81]2[cH:82][cH:83][cH:84][cH:85][cH:86]2)([c:87]2[cH:88][cH:89][cH:90][cH:91][cH:92]2)[c:93]2[cH:94][cH:95][cH:96][cH:97][cH:98]2)[P:99]([c:100]2[cH:101][cH:102][cH:103][cH:104][cH:105]2)([c:106]2[cH:107][cH:108][cH:109][cH:110][cH:111]2)[c:112]2[cH:113][cH:114][cH:115][cH:116][cH:117]2)([c:118]2[cH:119][cH:120][cH:121][cH:122][cH:123]2)[c:124]2[cH:125][cH:126][cH:127][cH:128][cH:129]2)[cH:130][cH:131]1>>[c:2]1(-[c:40]2[n:39][cH:38][c:37]([CH3:36])[s:41]2)[cH:3][c:4]([Cl:35])[c:5](-[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]([NH:16][c:17]4[cH:18][cH:19][c:20]([N:23]5[CH2:24][CH2:25][N:26]([CH3:29])[CH2:27][CH2:28]5)[cH:21][cH:22]4)[n:14][cH:15]3)[n:30]([CH2:33][CH3:34])[c:31]2=[O:32])[cH:6][cH:7]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-8b113a7af94c41af84b83e42b24278ed
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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