反应详情

A solution of 5-chloro-7-morpholinothiazolo[4,5-d]pyrimidine-2-carbaldehyde 43 (1.0 g, 3.5 mmol) in MeOH (30 mL) at 0° C. was treated with NaBH4 (0.1 g, 3.5 mmol). The solution was allowed to warm to room temperature and stirred 15 min. The reaction mixture was quenched with a mixture of a saturated solution of sodium bicarbonate and water (1:1, v/v). The aqueous solution was extracted with EtOAc. The combined organic layers were dried over Na2SO4 and concentrated in vacuo. The crude (5-chloro-7-morpholinothiazolo[4,5-d]pyrimidin-2-yl)methanol 56 required no further purification.

1. customThe reaction mixture was quenched with a mixture of a saturated solution of sodium bicarbonate and water (1:1
2. extractionThe aqueous solution was extracted with EtOAc
3. dry with materialThe combined organic layers were dried over Na2SO4
4. concentrationconcentrated in vacuo
5. customno further purification