HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalimide → 2-((5-Chloro-7-morpholinothiazolo[4,5-d]pyrimidin-2-yl)methyl)isoindoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(2-(Bromomethyl)-5-chlorothiazolo[4,5-d]pyrimidin-7-yl)morpholine | HCID 57685396 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-((5-Chloro-7-morpholinothiazolo[4,5-d]pyrimidin-2-yl)methyl)isoindoline-1,3-dione | HCID 57685413 | — |
Reaction Steps
To a solution of 4-(2-(bromomethyl)-5-chlorothiazolo[4,5-d]pyrimidin-7-yl)morpholine 57 in DMF was added K2CO3, and phthalimide. The resulting solution stirred 20 h at room temperature. The reaction was concentrated in vacuo and diluted with water (10 mL). The heterogeneous mixture was filtered to afford 2-((5-chloro-7-morpholinothiazolo[4,5-d]pyrimidin-2-yl)methyl)isoindoline-1,3-dione 58.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893059B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-6c9db91de50a44ce8365b15c2d306f31 |
| Source note | uspto-grants-2011_02 |