Morpholine → HCID 57685419, compound

HRID 1365780Notes

Reaction equation

HRID 1365780 reaction equation
[Cl:1][C:2]1[N:3]=[C:4](Cl)[C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[S:8][C:6]=2[N:7]=1.[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>CO>[Cl:1][C:2]1[N:3]=[C:4]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[C:5]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[S:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 57685417HCID 57685417, compound

Product 1

HCID 57685419HCID 57685419, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5,7-Dichloro-2-phenylthiazolo[5,4-d]pyrimidine 65 was suspended in methanol and treated with morpholine. The reaction mixture was stirred at room temperature for 4 h. Solid was filtered to yield pure 4-(5-chloro-2-phenylthiazolo[5,4-d]pyrimidin-7-yl)morpholine 66 as a beige solid.

Workup

  1. filtrationSolid was filtered

Sources & evidence

ORD record
ord-93b3aba909de422dbfc3c985c08d8f0d
Source dataset
uspto-grants-2011_02
Patent number
US07893059B2

Reaction notes

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