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HRID1365793

反应详情

EQUATION

反应方程式

HRID 1365793 的结构方程式

REACTANTS

反应物

2
结构：CC1(C)OB(c2cnc3[nH]ccc3c2)OC1(C)C
HCID24208789

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

C13H17BN2O2

结构：CS(=O)(=O)c1cccc(-c2nc3c(N4CCOCC4)nc(Cl)nc3s2)c1
HCID86630068

未命名化合物

PRODUCTS

生成物

1
结构：CS(=O)(=O)c1cccc(-c2nc3c(N4CCOCC4)nc(-c4cnc5[nH]ccc5c4)nc3s2)c1
HCID25254149

未命名化合物

收率 43.6%

PROCEDURE

实验过程

5-Chloro-2-(3-methanesulfonyl-phenyl)-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine (80 mg) was reacted with 54 mg of 5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine via General Procedure A. The product was purified by reverse phase HPLC to yield 41.8 mg of 109. MS (Q1) 493.2 (M)+.

WORKUP

后处理

  1. customThe product was purified by reverse phase HPLC