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HRID1365794

反应详情

EQUATION

反应方程式

HRID 1365794 的结构方程式

REACTANTS

反应物

2
结构：CN(C)c1ncc(B2OC(C)(C)C(C)(C)O2)cn1
HCID16414215

N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine

C12H20BN3O2

结构：CS(=O)(=O)N1CCN(Cc2nc3c(N4CCOCC4)nc(Cl)nc3s2)CC1
HCID44541675

未命名化合物

PRODUCTS

生成物

1
结构：CN(C)c1ncc(-c2nc(N3CCOCC3)c3nc(CN4CCN(S(C)(=O)=O)CC4)sc3n2)cn1
HCID25254150

未命名化合物

收率 10.7%

PROCEDURE

实验过程

5-Chloro-2-(4-methanesulfonyl-piperazin-1-ylmethyl)-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidine (80 mg) was reacted with 55 mg of dimethyl-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidin-2-yl]-amine via General Procedure A. The product was purified by reverse phase HPLC to yield 10.3 mg of 110. MS (Q1) 520.2 (M)+.

WORKUP

后处理

  1. customThe product was purified by reverse phase HPLC