Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (3-{[(Methanesulfonyl)amino]methyl}phenyl)boronic acid | HCID 22309453 | — |
| Reactant | 4-(5-Chloro-2-iodothiazolo[5,4-d]pyrimidin-7-yl)morpholine | HCID 25210284 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Sodium Carbonate | HCID 10340 | — |
| Product | HCID 86630071 | HCID 86630071 | 90.9% |
Reaction Steps
A mixture of 4-(5-chloro-2-iodothiazolo[5,4-d]pyrimidin-7-yl)morpholine 18 (400 mg, 1 mmol), 3-methanesulphonylaminomethyl benzeneboronic acid (260 mg, 1.1 mmol), bis(triphenylphosphine)palladium(II) dichloride (37 mg, 0.052 mmol) in 4 ml of acetonitrile and 4 mL of 1.0 M of sodium carbonate aqueous solution was heated to 100° C. in a microwave for 10 min. Water (5 mL) was added and the resulting solid was filtered and washed with water and ethyl acetate to yield crude N-[3-(5-Chloro-7-morpholin-4-yl-thiazolo[5,4-d]pyrimidin-2-yl)-benzyl]-methanesulfonamide (400 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07893059B2 |
|---|
| Source dataset | uspto-grants-2011_02 |
|---|
| ORD ID | ord-0863f2ebf4444d55b54bcb38185e006c |
|---|
| Source note | uspto-grants-2011_02 |
|---|
