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3-Methylsulfonylaminophenylboronic acid → HCID 86630072、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Methylsulfonylaminophenylboronic acid | HCID 2773535 | — |
| 反応物 | 4-(5-Chloro-2-iodothiazolo[5,4-d]pyrimidin-7-yl)morpholine | HCID 25210284 | — |
| 生成物 | HCID 86630072 | HCID 86630072 | — |
反応手順
4-(5-Chloro-2-iodothiazolo[5,4-d]pyrimidin-7-yl)morpholine 18 was reacted with 3-(methylsulfonylamino)phenylboronic acid via General Procedure A to give crude 3-(5-chloro-7-morpholinothiazolo[5,4-d]pyrimidin-2-yl)-N-methylsulfonylbenzenamine, which was then reacted with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine via General Procedure A again to give 121 after purification by reverse HPLC. MS (Q1) 485 (M+)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07893059B2 |
| 出典データセット | uspto-grants-2011_02 |
| ORD ID | ord-cb4c3c5c44714a30b1df5f98e6bf440e |
| 出典メモ | uspto-grants-2011_02 |