Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethyl orthoformate → 5-Chloro-2-((4-methylsulfonylpiperazin-1-yl)methyl)-7-morpholinothiazolo[5,4-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethyl orthoformate | HCID 9005 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 1-Methanesulfonylpiperazine hydrochloride | HCID 16265612 | — |
| 반응물 | 5-Chloro-7-morpholinothiazolo[5,4-d]pyrimidine-2-carbaldehyde | HCID 57685405 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 5-Chloro-2-((4-methylsulfonylpiperazin-1-yl)methyl)-7-morpholinothiazolo[5,4-d]pyrimidine | HCID 44541675 | — |
반응 단계
5-Chloro-7-morpholinothiazolo[5,4-d]pyrimidine-2-carbaldehyde was dissolved in dichloroethane with 1-methylsulfonylpiperazine hydrochloride (1.45 eq), sodium acetate (1.45 eq), and trimethylorthoformate (1.45 eq). The solution was stirred overnight. Sodium triacetoxyborohydride (1.35 eq) was added and after three hours at room temperature the reaction was quenched with saturated sodium bicarbonate solution. The aqueous was extracted with methylene chloride, dried with sodium sulfate and purified by silica gel chromatography to give 5-chloro-2-((4-methylsulfonylpiperazin-1-yl)methyl)-7-morpholinothiazolo[5,4-d]pyrimidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07893059B2 |
| 출처 데이터셋 | uspto-grants-2011_02 |
| ORD ID | ord-87c4a8662d8f439482d1fe507cecbb26 |
| 출처 메모 | uspto-grants-2011_02 |