HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyrimidine-5-boronic acid, pinacol ester → 5-(7-Morpholinothiazolo[5,4-d]pyrimidin-5-yl)pyrimidin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyrimidine-5-boronic acid, pinacol ester | HCID 17750212 | — |
| Reactant | 4-(5-Chlorothiazolo[5,4-d]pyrimidin-7-yl)morpholine | HCID 57685385 | — |
| Product | 5-(7-Morpholinothiazolo[5,4-d]pyrimidin-5-yl)pyrimidin-2-amine | HCID 25254772 | — |
Reaction Steps
4-(5-Chlorothiazolo[5,4-d]pyrimidin-7-yl)morpholine 14 was reacted with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidin-2-amine via General Procedure A to give 131 after purification by reverse HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07893059B2 |
| Source dataset | uspto-grants-2011_02 |
| ORD ID | ord-f74b0460d38e4712bdc65649735887b8 |
| Source note | uspto-grants-2011_02 |